Endocrine Abstracts

Introduction: 17 alpha-hydroxylase deficiency (17OHD) is a rare autosomal recessive disease caused by mutations in the CYP17A gene, representing 1% of cases of Congenital Adrenal Hyperplasia (CAH). The accumulation of mineralocorticoids and the glucocorticoid effect of corticosterone induce high blood pressure (HBP) and hypokalemia.Clinical Case: A 44 year-old female reporting HBP since the age of 20 years and without chronic medication, presented at the...

Background: Graves’ Disease (GD) is one of the most common organ specific autoimmune disorders, being characterized by an abnormal production of stimulating autoantibodies to the thyrotropin receptor (TSHR). Some studies demonstrated that genetic polymorphisms in certain cytokines, namely interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), are associated with a greater susceptibility of developing GD. Our aim was to evaluate ...

Introduction: Graves orbitopathy is the major extrathyroidal manifestation of Graves Disease (GD). The approach depends on its clinical activity and severity. Treatment and referral to specialized centers, with Endocrinology and Ophthalmology, has a strong impact on the prognosis of Graves’ Disease (GD) and GO.Cases report: We report four cases of DG with OG. Their characteristics and clinical evolution are shown in Table 1.<table boarder="1" ce...

Purpose: To assess the impact of serum corrected calcium (CorrCa), magnesium (Mg) and phosphorus (P) levels at hospital admission on SARS-CoV-2 infection outcome.Methods: In this retrospective study, all adult patients with laboratory-confirmed COVID-19 hospitalized in Hospital Universitario Puerta de Hierro Madadahonda during 2020 were included. Demographic, clinical and laboratory data were registered and related to the prognosis of the disease. Poor o...

Anamnesis: We report the case of a 54-year-old man who consulted for weight loss. He had been diagnosed with diabetes more than 20 years ago with good glycemic control (currently HbA1c 6.9%), no obesity, hypertension, or dyslipidaemia. A history of chronic pancreatitis and retinitis pigmentosa with eyelid ptosis. He maintains regular treatment with metformin, sitagliptin, repaglinide, ASA, Kreon and Pregabalin.Complementary testIn reference to the chief complaint, there had no...

Introduction: PTC patients with lymph node (LN) metastases of greater volume (in>5 LN and/or with larger metastases >5mm, hereinafter N1>5) usually receive radioiodine (RAI). Some guidelines suggest carrying out an evaluation of the response to surgical treatment (RST), recommending lower RAI dose (activity) in patients with good RST.Objectives: a)To evaluate the RST in patients with PTC and N1>5 b)To evaluate the disease-free-survival (D...

Background: Post surgery hypocalcemia is the most common sequel of thyroidectomy. An accurate prediction of hypocalcemia in the immediate postoperative period would enable the selection of patients for appropriate treatment and facilitate early discharge. Objective: This study aims to investigate the prevalence of hypocalcemia after thyroidectomy and to identify potential risk factors. Methods: This is a retrospective cohort study ...

Ectopic ACTH is rare and represents about 10% of causes of Cushing’s syndrome. Associated tumours are neuroendocrine in origin and include small cell lung cancer, carcinoid tumours, and medullary carcinoma of the thyroid. In this report, we describe a rare case of ectopic ACTH due to a primary pulmonary carcinoid tumour.A 29 years old male was diagnosed with hypertension 18 months prior to presentation. On ex...

Ectopic ACTH is rare and represents about 10% of causes of Cushing’s syndrome. Associated tumours are neuroendocrine in origin and include small cell lung cancer, carcinoid tumours, and medullary carcinoma of the thyroid. In this report, we describe a rare case of ectopic ACTH due to a primary pulmonary carcinoid tumour.A 29 years old male was diagnosed with hypertension 18 months prior to presentation. On ex...

Introduction: Acromegaly is a rare, progressive disease characterised by excess growth hormone. The recommended treatment is surgery. Radiotherapy and somatostatin analogues are used as adjuncts. The risk of post-radiotherapy osteosarcoma is 0.01% to 0.03% among all irradiated patients. We report a case of radiation-induced osteosarcoma that developed 22 years after radiotherapy for acromegaly.Case report: In 1997, a 53-year-old gentleman with acromegaly...